28th February 2020
Placeholder post. I’m reading/ hearing a lot of contradictory views about corona vaccine/ treatment, so will try to find the answer:
BIG PICTURE FACTS
“2019-nCoV (now called SARS-CoV-2) is the seventh member of the family of coronaviruses that infect humans, after MERS-nCoV and SARSnCoV” [Source].
AT PRESENT NONE OF THESE SEVEN ARE EITHER PREVENTABLE OR CURABLE:
- “No vaccine or antiviral is available for human coronavirus infections” [Source]
- “There are no specific antiviral medications approved for this disease. Symptoms are managed with supportive care.” [Source]
MY CURRENT SUMMARY ASSESSMENT
As I read more, I’ll update this assessment:
Although nothing is available today to prevent or treat coronavirus, there is a reasonable chance (not certainty) that (a) a treatment will be found before we get a vaccine; and (b) that at least one of these (vaccine or treatment) will be found in the next 12 months.
It is a good idea to not get the virus if one is above the age of 50. Preventative actions in the next 12 months could pay off in the future.
Prospect of vaccine
“a coronavirus vaccine is still months — and most likely years — away.” [Source]
“several research groups have reported the development of broad-spectrum and pan-coronavirus treatment and vaccine strategies, including those effective against both SARS-CoV and MERS-CoV.” [Source, 2017]
“In the light of a dwindling interest in SARS research in the last 5 years, MERS research has contributed to advancing the development of pan-coronavirus therapeutic options that are also effectively against SARS-CoV.” [Source, 2017]
Prospect of treatment options
An HIV protease inhibitor, lopinavir is being studied along with ritonavir for the treatment of MERS and SARS coronaviruses. The repurposed drug is already approved for the treatment of HIV infection under the trade name Kaletra [Source]
“The National Medical Products Administration of China has approved the use of Favilavir, an anti-viral drug, as a treatment for coronavirus. The drug has reportedly shown efficacy in treating the disease with minimal side effects in a clinical trial involving 70 patients. The clinical trial is being conducted in Shenzhen, Guangdong province.” [Source]
“Bruce Aylward, an assistant director-general of the World Health Organization (WHO), has stated “there is only one drug right now that we think may have real efficacy and that’s remdesivir.” It was reported on 25 February 2020 that clinical trials for this drug were in progress, with results possibly available within weeks” [Source]
An ebola drug developed by Gilead Sciences that was found to be ineffective is now being tested in phase III randomised clinical trial in partnership with China.
The trials are being performed on 761 patients in a randomised, placebo-controlled, double-blind study at multiple hospitals in Wuhan, the epicentre of the novel coronavirus outbreak. The results from the trials are expected to be available over the next few weeks.
According to a report by The New England Journal of Medicine (NEJM), remdesivir, when administered to a coronavirus patient in the US, appeared to have improved the clinical condition. [Source]
“Passive immunotherapy involving the administration of mAbs is a promising antiviral treatment and prophylactic strategy, as evident from ZMapp and palivizumab which can effectively prevent Ebola and respiratory syncytial virus infections in humans respectively” [Source, 2017]
SPECIFIC DETAILS ABOUT INDIVIDUAL CORONAVIRUSES
Middle East respiratory syndrome coronavirus (MERS-CoV)
MERS-CoV is a member of the subfamily Coronavirinae, genus Betacoronavirus, subgroup lineage 2c. Analysis of human MERS-CoV sequences has identified several circulating genotypes. These distinct genotypes are phylogenetically classified into clades A, B, and, most recently, C, which correlate with outbreaks of MERS among humans [Source]
MERS-CoV remains incapable of sustained human-to-human transmission [Source]
BACKGROUND: TYPES OF CORONAVIRUS
Although SARS-CoV and MERS-CoV are both classified under the order nidovirales and family coronaviridae, they are phylogenetically distinct, with SARS-CoV belonging to lineage B and MERS-CoV belonging to lineage C of the betacoronavirus genus. [Source, 2017]
22nd February 2020
The links below:
ALSO SEE MY RELATED ARTICLES
RSS is the greatest enemy of Hinduism
16th February 2020
For my record and reference – based on recent study. Of course, there are many other references to Dayanand on this blog over the years.
Dayanand Saraswati's "enlightened" caste system with two types of schools. – from Satyarth Prakash
Further details of how the "qualitative" (not hereditary) caste system should operate – Dayanand Saraswati's Satyarth Prakash
Dayanand Saraswati was smitten by the need to differentiate people. His theory was that these are not hereditary, but…
Dayanand Saraswati is crazy delusional when he says such things. Vivekananda at least recognised that "qualitative"…
It is amusing to read Dayanand's arguments that caste is real, but qualitative: "Since the divine formlessness and…
Here Dayanand Saraswati provides a mechanism to allocate "caste", but ALSO TO TAKE AWAY ONE'S CHILDREN!! Ghastly! Reminds me of Plato's Republic.Who in his right mind thinks up such rubbish?
15th February 2020
This is interesting – noting here for future reference: